Manufacturing News

Researchers map Salmonella genome

March 22, 2003
/ Print / Reprints /
/ Text Size+
Scientists at Washington University School of Medicine in St. Louis have mapped and sequenced the genome for Salmonella typhimurium, one of the leading agents of foodborne disease. According to researchers, the sequence has yielded new potential targets for future drug and vaccine development and gives possible insights into how the bacterium causes disease.

Typhimurium causes an estimated 1.4 million cases of food poisoning each year in the U.S., and about 1,000 deaths. Because antibiotic resistance is a growing problem with Typhimurium, researchers are hopeful that their map will help identify possible new drug targets and reduce the threat of resistant strains.

The investigators identified 4,595 suspected genes in the Typhimurium genome, many of which were previously unknown. They include 156 probable membrane proteins that are potential drug or vaccine targets.

The researchers also found two previously unknown gene clusters required for producing the hair-like strands, or fimbriae, that cover the bacteria. The strands enable the bacterium to cling to cells that line the intestines. "These are also targets for potential therapies that might prevent the bacterium from attaching in the gut and thereby preclude infection," said Sandra Clifton, Ph.D., research instructor in the Department of Genetics at Washington University and group leader for the project.

By comparing the genome of Typhimurium to several closely related bacteria, researchers discovered that the bacterium contains a series of mostly previously unknown genes that are missing from subspecies of Salmonella that infect cold-blooded animals. "Those genes may enable Typhimurium to infect warm-blooded hosts," says Clifton.

In addition to researchers at Washington University, the Typhimurium team included investigators at the Sidney Kimmel Cancer Center in San Diego; the University of Calgary in Alberta, Canada, and Pennsylvania State University.

Did you enjoy this article? Click here to subscribe to Food Engineering Magazine.

You must login or register in order to post a comment.



Image Galleries

Fabulous Food Plant: Paramount Citrus

Learn more about this fabulous food plant in Food Engineering's article, found here.


Burns & McDonnell project manager RJ Hope and senior project engineer Justin Hamilton discuss the distinctions between Food Safety and Food Defense as well as the implications for food manufacturers of the Food Safety Modernization Act.
More Podcasts


Food Engineering Magazine

Food engineering magazine 2014 april cover

2014 April

Catch a preview of the Powder and Bulk Show in this April 2014 edition of Food Engineering. Also, be sure to check out a coffee stick making a real stir and a major advancement in the the pet food industry.
Table Of Contents Subscribe


Food Authentication Using Bioorganic Molecules

This text provides critical tools and data needed to augment routine food analysis and enhance food safety by aiding in the detection of counterfeit, and potentially deleterious, foods.

More Products

Clear Seas Research

Clear Seas ResearchWith access to over one million professionals and more than 60 industry-specific publications,Clear Seas Research offers relevant insights from those who know your industry best. Let us customize a market research solution that exceeds your marketing goals.

Food Master

Food Master Cover 2014Food Master 2014 is now available!


Where the buying process begins in the food and beverage manufacturing market. 

Visit to learn more.


FE recent tweets