Meeting a range of cGMP and FDA guidelines, Comber Pressofiltro PF series Nutsche filter/dryers are built with CIP systems; the product contact wetted surfaces have no dead areas or bolted connections. The agitator arms utilize a tooth design to achieve low friction when pressing or smoothing the cake layer, while simultaneous rotational and vertical agitator motions evenly blend the product mass for mixing and drying. Product is discharged through a hydraulically operated side discharge valve, with the valve plug contoured to match the curvature of the vessel internal wall. It also can be discharged through an active or passive isolator.