This website requires certain cookies to work and uses other cookies to help you have the best experience. By visiting this website, certain cookies have already been set, which you may delete and block. By closing this message or continuing to use our site, you agree to the use of cookies. Visit our updated privacy and cookie policy to learn more.
This Website Uses Cookies
By closing this message or continuing to use our site, you agree to our cookie policy. Learn More
This website requires certain cookies to work and uses other cookies to help you have the best experience. By visiting this website, certain cookies have already been set, which you may delete and block. By closing this message or continuing to use our site, you agree to the use of cookies. Visit our updated privacy and cookie policy to learn more.
Food Engineering logo
search
cart
facebook twitter linkedin youtube
  • Sign In
  • Create Account
  • Sign Out
  • My Account
Food Engineering logo
  • Home
  • Magazine
    • Current Issue
    • Digital Edition
    • Archives
  • Exclusives
    • Fabulous Food Plants
    • Plant Construction Survey
    • Plant of the Year
    • Sustainable Plant of the Year
    • State of Food Manufacturing
    • Top 100 Food & Beverage Companies
    • Web Exclusives
  • Topics
    • Latest Headlines
    • Automation
    • Cannabis
    • Case Studies/Field Reports
    • Columns
    • Dry Processing
    • Food Safety
    • Innovation
    • Packaging
    • Processing
    • Sustainability
    • Tech Update
  • News
    • Manufacturing News
    • New Products
    • People & Industry News
    • Plant Openings
    • Recalls
    • Regulatory Watch
  • Food Master
  • Resources
    • Classified Ads
    • Custom Content & Marketing Services
    • FE Store
    • Government Links
    • Industry Associations
    • Market Research
    • White Papers
    • Tech Flash E-newsletter
  • Events
    • Calendar
    • Food Automation & Manufacturing Conference & Expo
  • Multimedia
    • Interactive Spotlights
    • Videos
    • Photo Galleries
    • Podcasts
    • eBooks
    • Food Plant of the Future
    • Webinars
    • Food Engineering's Youtube
  • Contact
    • Contact Us
    • Advertise
  • Subscribe
Home » Researchers map Salmonella genome
Manufacturing News

Researchers map Salmonella genome

March 22, 2003
Reprints
No Comments
Scientists at Washington University School of Medicine in St. Louis have mapped and sequenced the genome for Salmonella typhimurium, one of the leading agents of foodborne disease. According to researchers, the sequence has yielded new potential targets for future drug and vaccine development and gives possible insights into how the bacterium causes disease.

Typhimurium causes an estimated 1.4 million cases of food poisoning each year in the U.S., and about 1,000 deaths. Because antibiotic resistance is a growing problem with Typhimurium, researchers are hopeful that their map will help identify possible new drug targets and reduce the threat of resistant strains.

The investigators identified 4,595 suspected genes in the Typhimurium genome, many of which were previously unknown. They include 156 probable membrane proteins that are potential drug or vaccine targets.

The researchers also found two previously unknown gene clusters required for producing the hair-like strands, or fimbriae, that cover the bacteria. The strands enable the bacterium to cling to cells that line the intestines. "These are also targets for potential therapies that might prevent the bacterium from attaching in the gut and thereby preclude infection," said Sandra Clifton, Ph.D., research instructor in the Department of Genetics at Washington University and group leader for the project.

By comparing the genome of Typhimurium to several closely related bacteria, researchers discovered that the bacterium contains a series of mostly previously unknown genes that are missing from subspecies of Salmonella that infect cold-blooded animals. "Those genes may enable Typhimurium to infect warm-blooded hosts," says Clifton.

In addition to researchers at Washington University, the Typhimurium team included investigators at the Sidney Kimmel Cancer Center in San Diego; the University of Calgary in Alberta, Canada, and Pennsylvania State University.

subscribe to Food Engineering

Related Articles

Researchers zero in on Listeria genome

Electron beam food research facility dedicated at Texas A&M

MAP packs using CO under scrutiny

Report says USDA, FDA research and rules still need work

You must login or register in order to post a comment.

Report Abusive Comment

Subscribe For Free!
  • Print & Digital Edition Subscriptions
  • eNewsletter
  • Online Registration
  • Subscription Customer Service

More Videos

Popular Stories

North Carolina Food Innovation Lab

North Carolina Food Innovation Lab takes aim at food production of the future

sustainable packaging

Packaging industry pumps up R&D to keep pace with green goals

BKON's RAIN technology

RAIN uses vacuum cycles for extraction to occur at the deepest layers of coffee

Plant Opening

Plant Openings & Expansions: November 2019

date labels

Much food waste comes from misinterpretation on product date labels

Food Master 2020

Events

December 11, 2019

7 Things You’re Likely Missing to Win with Water Tracking

Water is one of the most critical resources in your manufacturing process—as an ingredient, for cleaning and as waste. Did you know you may be missing areas to monitor that could help your bottom line? Find out how some simple additions to what you’re monitoring can cut downtime, boost efficiency and reduce waste. Some extra analysis makes a huge difference in your water savings!
April 26, 2020

Food Automation & Manufacturing Conference and Expo

FA&M logoFood Engineering's Food Automation & Manufacturing Conference and Expo (FA&M) is a 2 ½ day event that brings food and beverage processors and suppliers together to gain valuable information on the latest trends and technologies in manufacturing, automation, sustainability and food safety.

View All Submit An Event

Poll

Severe Weather and the Supply Chain

How will this year’s severe spring weather affect your supply chain?
View Results Poll Archive

Products

Packaging Research in Food Product Design and Development

Packaging Research in Food Product Design and Development

Packaging Research in Food Product Design and Development is the first book to comprehensively address the issues of graphics design and visual concepts, from a systematic, scientific viewpoint, yet with business applications in mind.

See More Products

2019 Top 100 Food & Beverage Companies

Food Engineering

FE November 2019 cover

2019 November

In the November 2019 issue of Food Engineering, learn about the new ways food and beverage processors are reducing their energy footprints.
View More Create Account
  • Resources
    • Food & Beverage Brands
    • List Rental
    • Survey And Sample
  • Want More
    • Connect
  • Subscribe
  • Privacy Policy

Copyright ©2019. All Rights Reserved BNP Media.

Design, CMS, Hosting & Web Development :: ePublishing